Randomized clinical trials (RCT’s) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy.
Level 1 evidence was found for bladder cancer, breast cancer, cervical cancer, cancer of the esophagus, lymph nodes of head and neck tumors, rectum cancer, soft tissue sarcoma, malignant melanoma, glioblastoma multiform, and various superficial cancers.
Heat is known to kill cancer cells, shrink tumor size, increase radiosensitivity, inhibit DNA repair, oxygenate hypoxic tumors, produce heat shock proteins and increase disease free survival.
Hyperthermia is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 113°F).
Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues.
The Journal of the American Medical Association (JAMA) just published a 10 year patient follow-up to a phase III clinical study on a Soft Tissue Sarcoma Study. In addition to higher CR, the addition of hyperthermia increased the median long-term survival rate from 6.2 to 15.4 years
Benefits of Hyperthermia in Cancer Treatment
In the delicate micro-environment of a cancer cell, heat can lead to direct cell death, shrinking tumors size for easier surgical resection.
A phase III clinical study shows an increased survival benefit when hyperthermia was added to chemotherapy.
Very low to no toxicity is often reported when administering hyperthermia. There is no known toxicity build-up from multiple treatments.
Inhibits DNA Repair
Hyperthermia in combination with Radiotherapy will inhibit the DNA repair cycle of radiation damaged cancer cells.
Increase Blood Flow
Increased blood flow and perfusion at the tumor site promotes oxygenation, increasing radiosensitivity.
Heat Shock Proteins
Tumor cells express heat shock proteins when exposed to hyperthermic temperatures allowing tumor specific antigens to reach the immune system.